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The influence of caffeine, administered to rats, on the somatic and sensory-motor development of the offspring was investigated. Female Wistar rats were divided into a control group and a treated group and received drinking water and a 0.1% solution of caffeine orally, respectively. The offspring, also divided into a control group and a treated group, received daily monitoring until the 20 th day of life to verify alterations in somatic neural development. The offspring of the treated group had reduced weight on the day of birth and on the 1 st , 5 th , 15 th and 20 th days of life; shorter snout-anus length (evaluation done daily); shorter snout-tail length on the day of birth and on the 1 st , 5 th and 10 th days of life, and signs of retardation of somatic and sensory-motor maturation. These results allowed the conclusion that administration of caffeine to rats affects somatic and sensory-motor development of offspring.Uniterms: Caffeine/effects. Postnatal development. Central nervous system/stimulants. Estudou-se a influência da cafeína, administrada a ratos, no desenvolvimento somático e sensorial-motor da prole. Ratos Wistar fêmeas foram divididos em grupo controle e grupo tratado e receberam água e solução de cafeína a 0,1%, respectivamente. A prole, também dividida em grupo controle e grupo tratado, foi monitorada diariamente até o 20º. dia de vida para se observar as alterações no desenvolvimento somático neural. O grupo tratado apresentou peso reduzido no dia do nascimento e nos 1º, 5º., 15º e 20º. dias de vida; comprimento focinho-ânus mais curto (avaliação efetuada diariamente); comprimento focinho-cauda mais curto no dia do nascimento e nos 1º, 5º., 15º e 20º. dias de vida e sinais de retardamento da maturação somática e sensorial-motora. Esses resultados permitem que se conclua que a administração da cafeína a ratos afeta o desenvolvimento somático e sensorial-motor da prole.Unitermos: Cafeína/efeitos. Desenvolvimento pós-natal. Sistema Nervoso Central/estimulantes.
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