No abstract

Electrochemical synthesis became one of the emerging and powerful tools to create novel state-of-the-art strategies for an assembly of complex organic molecules. However, electrochemically-induced N-N bond forming reactions still remain...

A direct approach toward the construction of furoxan-sydnone imine double NO-donors involving the NOBF4-mediated nitrosation-cyclization sequence of α-amino nitriles as a key synthetic step was developed. The described protocol excludes the formation of carcinogenic N-nitrosamines, operates broad substrate scope and enables a preparation of fully substituted sydnone imines linked to the furoxan ring via different linkers or directly through C-C bond. Synthesized library of furoxan-sydnone imine hybrids demonstrated a promising ability to release NO in a wide range of concentrations which is useful for various biomedical insights.