Advances in noninvasive hemodynamic monitoring systems allow delivery of goal-directed fluid therapy and could therefore be used in less-invasive surgical procedures. In this randomized controlled trial, we compared closed-loop-assisted goal-directed fluid therapy using a noninvasive cardiac output (Clearsight system) monitor (personalized approach) to a protocolized fluid therapy approach in 40 patients undergoing moderate-risk laparoscopic abdominal surgery. Cardiac output and stroke volume variations were not significantly different in both groups and remained within predefined target values >90% of the study time. Personalized fluid therapy does not seem to offer any hemodynamic advantage over a protocolized approach in this population.
În lucrare s-a argumentat necesitatea fortificării băuturilor de fructe cu micro- şi macroelemente. S-au selectat cei mai potriviți compuşi ai fierului şi ai calciului pentru fortificare, tipul băuturilor şi s-au argumentat ştiinţific dozele introducerii acidului ascorbic necesare pentru asimilarea fierului. S-a demonstrat necesitatea alegerii tipului de băuturi pentru fortificare în funcție de gradul de limpezire şi selectarea compuşilor macro- şi microelementelor după compatibilitatea cu compoziţia băuturilor. Sunt prezentate rezultatele determinării caracteristicilor organoleptice şi fizico-chimice ale băuturilor fortificate în scopul stabilirii termenului de valabilitate.
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