Anaphylaxis is a rare condition in pregnancy. Drugs are the aetiological agents most often implicated. Maternal anaphylaxis can lead to significant fetal morbidity and even mortality if uterine perfusion and maternal oxygenation are compromised. Significant risk of neonatal neurological damage or death can occur even when the maternal clinical outcome is favourable. The authors present the case of a newborn, born at gestational age of 29 weeks, who died at 11 days of life with hypoxic–ischaemic cerebral injuries as a consequence of maternal anaphylaxis following the administration of amoxicillin in the community setting.

Congenital sternal malformation is a rare anomaly often diagnosed as an asymptomatic condition at birth. The authors report a clinical case of a full-term female neonate with congenital sternal cleft and partial ectopia cordis. Successful surgical repair was accomplished at 6 days of age. When surgery is performed shortly after birth, the procedure is easier and better results are achieved.

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RESUMOA pneumonia organizativa fibrinosa aguda é uma entidade histológica, incluída no grupo das doenças pulmonares intersticiais, com múltiplas etiologias, incluindo a toxicidade farmacológica. Os autores descrevem o caso de um homem de 73 anos, com diagnóstico de linfoma linfoplasmocítico, sob tratamento de manutenção com rituximab após quimioterapia. O doente desenvolveu um quadro clínico insidioso caracterizado por tosse não produtiva, dispneia e astenia. A integração dos aspetos imagiológicos e da histologia de biópsia pulmonar conduziram ao diagnóstico de pneumonia organizativa fibrinosa aguda. Após suspensão do fármaco e instituição de corticoterapia o doente apresentou evolução clínica e imagiológica favorável. Dada a utilização crescente de terapêuticas-alvo em oncologia, o presente caso pretende contribuir para o reconhecimento desta entidade como potencial evento adverso. PALAVRAS-CHAVE:Pneumonia em Organização Criptogénica/diagnóstico; Pneumonia em Organização Criptogénica/induzida quimicamente; Pneumonias Intersticiais Idiopáticas; Rituximab/efeitos adversos ABSTRACT Acute fibrinous organizational pneumonia is a histological entity included in the group of interstitial lung diseases, with multiple etiologies including pharmacological toxicity. The authors describe the case of a 73-year-old man diagnosed with lymphoplasmacytic lymphoma under maintenance treatment with rituximab after chemotherapy. The patient developed an insidious clinical picture characterized by non-productive cough, dyspnea and asthenia. The integration of imaging aspects and pulmonary biopsy histology led to the diagnosis of acute fibrinous and organizing pneumonia. After suspension of the drug and institution of corticosteroids, the patient presented a favorable clinical and imaging course.