Introduction: Pancreatic cancer is a pathology with high lethality and increasing incidence worldwide. In this sense, it is a condition characterized by being usually detected in advanced stages, thus contributing to low five-year survival rates for patients. On the other hand, treatment of pancreatic adenocarcinoma is evolving with the introduction of new surgical techniques and medical therapies. Objective: to outline, through an integrative review, the most upto-date knowledge on current treatment data and innovative approaches related to pancreatic adenocarcinoma while identifying gaps that aim to stimulate further research on this malignancy. Method: Integrative literature review whose searches were carried out through the association of descriptors and keywords in the Pubmed database. Result: This review analyzed selected articles and published between the years 2015 -2022 and identified knowledge deficits, especially regarding the development of effective techniques for the treatment of pancreatic cancer. Conclusion: Although there is a great effort to optimize diagnosis and treatment, currently, patients who develop pancreatic adenocarcinoma are still subjected to inefficient medical care processes.