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We propose an optimized U-Net architecture for a brain tumor segmentation task in the BraTS21 Challenge. To find the optimal model architecture and learning schedule we ran an extensive ablation study to test: deep supervision loss, Focal loss, decoder attention, drop block, and residual connections. Additionally, we have searched for the optimal depth of the U-Net and number of convolutional channels. Our solution was the winner of the challenge validation phase, with the normalized statistical ranking score of 0.267 and mean Dice score of 0.8855.

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