A direct palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine with aryl bromides has been developed. This reaction is quite general with respect to the aryl or hetaryl bromide.

Palladium-Catalyzed Highly Regioselective C-3 Arylation of Imidazo[1,5-a]pyridine. -With respect to the aryl and hetaryl bromide a rapid and general method for the synthesis of the compounds (III) and (V) is presented. -(HUANG, C.; GIOKARIS, A.; GEVORGYAN*, V.; Chem. Lett. 40 (2011) 9, 1053-1054, http://dx.doi.org/10.1246/cl.