In this randomized clinical trial comparing micafungin 100 mg with standard-care antifungal prophylaxis (fluconazole, liposomal amphotericin B, or caspofungin) in high-risk liver transplant patients, micafungin 100 mg was noninferior and had a better kidney safety profile.

Leiomyosarcoma of the inferior vena cava (IVC) is a rare malignancy. Approximately 350 cases of this disease are known worldwide. Surgical treatment of this condition remains an extremely difficult task. In this case report, we present an experience of successful radical treatment of a leiomyosarcoma of the suprarenal IVC without vascular reconstruction. The patient was treated with resection of the suprarenal portion of the IVC with the tumor; however, in view of adequate blood outflow from the right lobe of the liver, prosthetic replacement of the IVC with right hepatic vein reimplantation was not performed.

Data concerning history of hepatic surgery beginning from the Middle Ages to current days are presented. On the first stage (till XIX century), representatives of medical profession had schematic ideas on hepatic anatomy and operations on this organ were perforemed sporadically. On the second stage (first half of the XX century), segmental hepatic anatomy was established, different technical methods concerning identification of shared and segmental pedicles were offered. Planned resections of the liver began to be regularly performed in this period. Current, third stage of the surgery development was marked by the synthesis of achievements in the area of hepatic anatomy and surgery with revolutionary discoveries in high technology area, immunology, tissue compatibility and pharmacology. Such surgeries became to be possible as transplantation of the liver, broadened resections and extracorporeal interventions performed on the liver.

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