Untimely diagnosis of the oral cavity leads to an underlying periodontal inflammation. Therefore, it was raised an issue of psychological correction in patients with inflammatory periodontal diseases where it was observed the role of mental state and the importance of the addition of this therapeutic component to a comprehensive program for the treatment of patients in dental clinics is emphasized. The study consisted of two stages: diagnostic and therapeutic. The first stage included 76 patients who needed an examination to detect periodontal inflammation; these patients were examined using the Fluorit-4S therapeutic and diagnostic device (TDD). The second stage of the study included 28 patients with inflammatory periodontal diseases. Patients of the study group (14 people) received treatment using a mesodiencephalic modulation method (MDM-therapy). It was proved the possibility of earlier detection of periodontal inflammation (even at the level of a "latent" process) using the Fluorit-4S device. Higher therapeutic efficacy of comprehensive dental treatment in patients with periodontal inflammation using the Fluorit-4S TDD and MDM-therapy was proved compared to standard therapeutic strategy in terms of more evident reduction in local discomfort (by 0.5 points compared to the control group), more significant decrease in the PMA index (an index that measures the presence or absence of gingival inflammation as occurring on the papillae or the marginal or attached gingivae) (by 0.9% compared to the control group), fuller elimination of the pathological focus, as well as a complete normalization of the emotional state. The use of the Fluorit-4S TDD in dental practice allows dentists to study the affected tissues more closely, resulting in objective conclusions on the pathological processes in the oral mucosa and, accordingly, the selection of adequate therapeutic strategies for individual clinical cases.