Scales were taken from 128 human volunteers suffering from ringworm infections and grown on Sabourand's media to determine the type of organisms causing the disease. Groups of 32 patients each were treated for sixty days with griseofulvin tablets containing dioctyl sodium sulfosuccinate, cetyl pyridinium chloride and polysorbate 80 respectively, while another group of 32 was given tablets containing griseofulvin only for the same period. The subjects treated with griseofulvin tablets containing surfactants showed a higher rate of cure than those treated with griseofulvin alone.

The biological activity of Pantheno1,Chlorphenesin and Lignocaine medicated solidified sodium stearate-based sticks (SSSS) was evaluated in an assessment of the suitability of this dosqe form for topical treatment.Panthenol sticks were evaluated as to tHeir healing promoting activity by producing sterile ulcerated circular areas on the shaved hind limbs of m l e albino rats,applying a definite amount of the drug to them and observing their rate of healing.Chlorphenesin sticks were evaluated as to their antifungal and mtibacterial effects on two fungi ,Trichophyton mentagrophytes and Candida albicans as \,ell as on Staphylococci.This necessitated a prior-screening of the base ccqonents ,viz.alcohol and humectants indjvidually f o r these effects on culture media using Sabouraud's glucose-agar and blood-agarino effect was noticed.The activity of the sticks was then studied by infecting about 5cm with the microorganisms,applyirg a definite .amount of the drug 2 of the scratched skin of the f o i r r limbs of guinea pigs 685

No abstract

Synopsis A comparative study was conducted on the influence of widely used humectants [glycerol, propylene glycol (PG), polyethylene glycols 400 and 600 (PEG 400 and PEG 600)] on the physical characteristics of solidified sodium stearate-based sticks (SSSS). - Sticks prepared with PG or PEG 600 generally tended to be harder than the corresponding ones containing glycerol or PEG 400; - PG lowered the penetrability of the sticks while PEG 400 tended to increase it. Glycerol or PEG 600 produced sticks with intermediate penetrability values; - all investigated sticks showed practically acceptable softening points; - PG-based sticks showed the lowest yield by abrasion values while PEG 400-based ones showed the highest such values. Glycerol or PEG 600 produced sticks with intermediate behaviour; - sticks prepared with PG generally showed the highest tendency to dry by evaporation. There was a clear tendency towards reduction in evaporation with all the considered humectants, proportional to humectant concentration increase; - sticks formulated with PEGs showed considerably longer disintegration times than those formulated with glycerol or PG; - all sticks showed a plastic thixotropic flow behaviour; - static and dynamic yield value-humectant concentration curves exhibited an almost identical behaviour with all investigated systems; - generally speaking, SSSS with PG showed the highest dynamic and static yield values while those formulated with PEG 400 showed the lowest such values; the presence of PEG 400 or glycerol resulted in sticks with intermediate behaviour in this respect; - PG produced sticks showing the highest thixotropic breakdown by shear; glycerol came next in this respect. PEG-based sticks showed strong fluctuations in their thixotropic breakdown-humectant concentration behaviour; - PG gave sticks with the highest plastic viscosity; they, indeed, had a tough texture. Glycerol or PEG 600-based sticks had intermediate plastic viscosities and acceptable spreading characteristics. PEG 400-based sticks had the lowest plastic viscosity and best spreading characteristics; - almost all sticks investigated proved to be stable after 18 months storage as far as.

No abstract