Membrane Computing (MC) is defined as one of the main areas in computer sciences; MC has the aim of discovering novel computational models from studying biological cells, specifically the cellular membranes. Mitogen-Activated Protein Kinases (MAPK) cascade was the subject of research in the areas of modeling and simulation. Various software tools such as Performance Evaluation Process Algebra (PEPA) have been used to solve the MAPK cascade for the purpose of improving the effectiveness of signaling. In this study, the MAPK cascade is modeled by using MC. The models of Membrane Computing could be totally fully utilized by applying parallel computing platforms. P-Lingua can be defined as a programming language for MeCoSim and MC, where MC simulators are used to model and simulate MAPK. P-Lingua will be applied to structure, develop and examine the implementation of MAPK cascades in membrane computing. MeCoSim supports charts, outputs, and inputs which have been adapted to MC. The simulation results have been put to comparison with PEPA model. The results indicate that MC improves the MAPK implementation compared to PEPA. This study showed that MC, with its biological characteristics, could improve the implementation regarding biological processes including MAPK.
Deep learning algorithms rely on digital pathology to classify tissue tumors, where the whole tissue slides are digitized and imaged. The produced multi-resolution whole slide images (MWSIs) are with high resolution that may range from about 100,000 to 200,000 pixels. MWSIs are often stored in a multi-resolution configuration to simplify the processing of images, navigation, and efficient exposition. This work develops a network for classifying MWSIs that require high memory employing a deep neural Inception-v3 architecture. This work employs the MWSIs from Camelyon16, which is around 451 GB in size of Challenge dataset from two independent sources including 400 MWSIs as a total of lymph nodes. The training dataset contains 111 MWSIs of tumor tissue and lymph nodes and 159 WSIs of normal lymph nodes. The developed model uses sample-based processing to train extensive MWSIs employing the MATLAB platform. The model introduces transfer learning techniques with an Inception-v3-based architecture to categorize separate samples as a tumor or normal. Therefore, the main aim here is to achieve two-classes binary segmentation containing normal and tumor. This includes creating a new fully connected layer for the Inception-v3 architecture with two classes and compensating new layers instead of the original final fully-connected layers. The results obtained demonstrated that the heatmap visualization can recognize the boundary coordinates of ground truth as sketchy Region Of Interest (ROI), where the green boundary represents the normal regions and the tumor area with red boundaries. The proposed Inception v3 Convolutional Neural Network (CNN) architecture can achieve more than 92.8 % accuracy for such MWSIs dataset to categorize brain tumors into normal and tumor tissue
Word sense disambiguation (WSD) refers to determining the right meaning of a vague word using its context. The WSD intermediately consolidates the performance of final tasks to achieve high accuracy. Mainly, a WSD solution improves the accuracy of text summarisation, information retrieval, and machine translation. This study addresses the WSD by assigning a set of senses to a given text, where the maximum semantic relatedness is obtained. This is achieved by proposing a swarm intelligence method, called firefly algorithm (FA) to find the best possible set of senses. Because of the FA is based on a population of solutions, it explores the problem space more than exploiting it. Hence, we hybridise the FA with a one-point search algorithm to improve its exploitation capacity. Practically, this hybridisation aims to maximise the semantic relatedness of an eligible set of senses. In this study, the semantic relatedness is measured by proposing a glosses-overlapping method enriched by the notion of information content. To evaluate the proposed method, we have conducted intensive experiments with comparisons to the related works based on benchmark datasets. The obtained results showed that our method is comparable if not superior to the related works. Thus, the proposed method can be considered as an efficient solver for the WSD task.
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