Background & Objectives:Saleint decrease in physical activity, including problems that are frequently observed in hemodialysis patients .Inversely, the performance level of hemodialysis patients related to with major health consequences such as health care costs and mortality. This study determined the Effect of Care Plan Based on the ROY ADAPTATION MODEL on Activities of Daily Living of hemodialysis Patients Material & Method: This clinical trial research was performed on 54 hemodialysis patients (28 intervention and 26 control patients). The intervention group received the RAM program through a face to face process with 4 sessions at 3-week interval followed by a follow-up period of 4 weeks, while the control group received the regular services from hospital. The data collected by using of patient identification form, Inventory of Functional Status-Dialysis and Roy assessment tool. Data were analyzed with SPSS. Results: The results indicate that the between two groups were not different on Activities of Daily Living (p=0.060) before the intervention but they were significantly different after the intervention. Patients' Activities of Daily Living improved in patients in the intervention group. Conclusion: The findings of this study indicate that the Care Plan Based on the ROY ADAPTATION MODEL is a low cost nursing intervention for Activities of Daily Living improved in Hemodialysis Patients.