Major depressive disorder is a serious and disabling disease in world; it is a most common chronic and recurrent disorder with fourth cause of loss in disability in the worldwide. Objectives: To evaluate the efficacy and adverse effects of Paroxetine in major depressive disorder patients. Study Design: Open Labeled study. Setting: Department of Psychiatry, Chandka Medical College Hospital Larkano. Period: Three months (August to October 2019). Material & Methods: Total 40 patients of either sex were enrolled from OPD of Psychiatric department with age of 18 to 65 years. Follow-up visits were carried out fortnightly after making evaluation on symptoms at base line visit (day 0) continued till 90 days, and then results were compiled. The SPSS-16 version was used for the analysis of data. Results: Paroxetine is highly significant (p=0.001) to decrease the symptoms of depression during treatment of 90 days. Conclusion: In this study, Paroxetine is more effective drug to decrease the symptoms like, weight loss, sexual disturbance, insomnia and with less adverse effects in patients of major depressive disorder.

Aim: To evaluate the pharmacological effects of pumpkin seeds in correlation to weight gain in rabbits. Methodology: After observing as standard inclusion and exclusion criteria, thirty healthy adult rabbits recommended in study. Calculated amount 250 mg and 500 mg of powder of pumpkin seeds given. 1stanalysis denoted as day zero. Afterward more analysis were taken twice monthly for sixty days. The blood specimens passed immediately to the DR Lab by the side at the PUMHS Nawabshah. CBC analyzed using an automatic hemoglobin analyzer. Data were statistically evaluated in groups as mean by t-test and by SPSS version 21.0. A P value of 0.05 for all comparisons counted significant. Results: While comparing study groups with control, the mean Haemoglobin, RBCs and Platelets value at day zero were established as non-significant statistically. TLC and Weight means were significant statistically. A rising boost observed on further readings taken in all Hematological parameters. When compared with control, all the interpretation was highly significance statistically except weight which remains non-significant statistically. Conclusion: Pumpkin seeds can be replaced by ordinary method as a best plant food supply for improving hematological markers. It bears no any side effect of weight gain or patients non- cooperation like with medical therapy because of its high cost or side effects.

Objective: To evaluate pumpkin seeds effects on improving low haemoglobin level in rabbits. Study Design: Experimental study. Setting: Pharmacology Department PUMHSW, Nawabshah. Period: January 2020 to March 2020. Material & Methods: Thirty adult health rabbits were chosen for the study by keeping inclusion and exclusion criteria as standard. Pumpkin seeds powder measured quantity 250 mg and 500 mg was given to different groups for 60 days as once a day respectively. The samples of blood were taken at standard equal. At zero time, first reading marked as day 0. Thereafter further samples were taken twice monthly for 60 days. Complete Blood Count was analyzed with Automatic Hemoglobin Analyser. Data was assessed statistically in groups as means through correlated pairs t test and thru SPSS version 21.0. For all comparisons, upto 0.05 P value was considered significant. Result: The mean Haemoglobin values on day 0 were found non-significant statistically within study groups while comparing with control. Whereas, there a growing increase from day 15 to day 60 was observed in the Haemoglobin mean values in group B and C on all successive reading taken twice monthly. All the interpretation creates highly significance statistically when as compared with control. It shows the pumpkin seed’s haematopoietic effect in anaemia cases due to iron deficiency. Conclusions: Seeds of pumpkin can be substituted with common methods as a good plant nutritional source for to improve haemoglobin in anaemia due to iron deficiency.