Studies and reports suggested that bed bug infestation has been increasing rapidly in the United States since 2004. Scientists suggested that the reason for this resurgence of bed bugs is the less use of pesticides and the international immigration where foreign people carry bed bugs with them into the country. The main purpose of this review is to study the causes of the rapid bed bugs' infestation and its effect on human health. It will also discuss the best ways to control this epidemic. This review article was written and designed based on reviewing many research articles, scientific books, and science based websites that had done researches on the epidemiology of bed bugs and its effect on human health. In addition, this review also discussed the best strategies and solutions that can be used to eradicate bed bugs including, collecting of data, understanding the reasons of the problem, and intervening of government. In conclusion, bed bugs' infestation is still increasing and spreading in the United States. Developing a new effective insecticide and new government legislations are essential to eradicate this epidemic.