As a result of the increasing needs among the public to enhance esthetics, many approaches have been made and the results included different approaches as non-metallic tooth-colored restorations, including the direct and indirect resin composites. In addition, another approach is the ceramic onlays or inlays. In this study, we aim to formulate strong evidence regarding the differences between direct and indirect resin composite the clinical outcomes, and related effects on esthetic restorations, based on evidence obtained from the current and previous studies in the literature. Many differences were discussed within the study manuscript between the direct and indirect resin groups. Furthermore, evidence shows that esthetic outcomes are in favor of the latter. We also discussed the color stability outcomes for the two groups and evidence in this area was controversial. Finally, many studies have reported that the clinical efficacy of the indirect resin composites is superior to the direct ones, while many others reported that they are similar, and only a few reported that direct resin composites are superior. Accordingly, further studies are encouraged to unify these contradicting results.