Dengue fever (DF)/dengue hemorrhagic fever (DHF) has emerged as a global public health problem with countries in Asia and the Pacific sharing more than 70% of the disease burden. In 2004-2005 a total of 312 cases admitted to Pediatric and Sea Port Hospitals in Port Sudan were clinically diagnosed as DHF. The mortality rate recorded was 3.8% (n=12). Of the cases 73.4% were patients 5-15 years of age. A total of 91.2% of cases were admitted during May and June 2005 with 49.4% residing in the eastern region of Port Sudan. Dengue shock syndrome was observed in 37 of 312 (11.9%). All patients had thrombocytopenia with platelets count ranged from <100,000 to <150,000 cell/mm³. Of the 40 sera tested using RAPID-cassette test in the Khartoum Central Public Health Lab, 36 (90%) were dengue IgM positive. A subset of these sera (n=23) were sent to NAMRU-3 and confirmed by IgM-capture ELISA; 9 of 23 were PCR positive for dengue serotype 3.

Background: Although peripheral lymphadenopathy is a common presentation in Red Sea State, Sudan, no previous work was made to assess its causes. So, this study is done to identify the underlying causes of peripheral lymph nodes enlargement in the adult patients.

Dengue is a global endemic and most prevalent human arbovirus disease. This study aimed at evaluating thrombocytopenia and to find out platelet activation in dengue across the spectrum of the disease. A prospective study was conducted from February, 2013 to June, 2014 at Port Sudan Teaching Hospital, Red Sea State, Sudan. 334 cases of dengue caused by dengue virus along with 101 cases of control were enrolled. Laboratory-positive dengue cases were confirmed by immune chromatography and World Health Organization (WHO) criteria were used for classifying the dengue severity. Platelet counts (PLT) and platelet distribution width (PDW) were measured. Out of 334, 289 patients had dengue fever (DF) and 45 patients had dengue haemorrhagic fever (DHF). Thrombocytopenia was present in 234 (81%) DF cases and 45 (100%) DHF cases. Bleeding manifestation was seen in 35 (10.5%) patients. Haematuria (5.7%), haematamesis (0.3%), haemoptysis (0.3%), epistaxis (1.5%), and gum bleed (2.7%) are the common forms of bleeding. PLT and PDW were found to be significantly low and high in case of dengue (P < 0.000), respectively. Thrombocytopenia (low PLT) and high PDW shows considerable sensitivity for dengue virus infection.

Background and aim: Celiac disease is characterized by sensitivity to gluten that results in

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