No abstract

Steroidal building blocks have drawn research groups attention in many branches of science and technology, such as pharmacological and medical fields, supramolecular chemistry and compounds in nanotechnology, So the recent years have witnessed a wide focus of research directed towards preparing heterocyclic derivatives fused with steroid molecules as a result of the great biological activity these compounds, This review described an outline of the literature reports (2014-2020) of synthesis heterocyclic compounds for steroid molecules fused at rings-A or B or D of steroid skeleton or annealed, Also the review included the biological activity of steroid hetero cyclic as anti breast cancer, anti prostate cancer, antioxidant and antimicrobial.

The search includes a new series of hydrazide- hydrazone derivatives [12-14] as well as 1,3,4- Oxidiazole[7, 8] for steroid analog (methyl((5-pregnen-3β,17-diol-15-yl) thio) propanoate) were synthesized throw react ester group with Hydrazine Hydrate in presence DMF to obtained carbohydrazide derivative (4), then the 1,3,4-Oxodiazole are prepared by interaction Benzoic Acid substituted with steroid (4) in presence Phosphorous Oxy Chloride as catalyst. while Hydrazide-hydrazone are prepared by react the steroid (4) with aromatic aldehydes or ketone by catalyzes HOAc. Structures of all the newly synthesized compounds have been elucidated by means of IR, 1H NMR, 13CNMR,2D (HMBC, HSQC) and C.H.N Analysis.

The number of steroids and their derivatives possess divers pharmacological activities as drugs for the treatment of a large number of diseases so in this work was suggested prepared two series amides and pyrazoles of steroid analogs ( methyl((5-pregnant-3β,17-diol-15-yl) thio) propanoate) . Amides derivatives ( 6 -9 ) prepared directionally after treated the steroid analogs with primary amine substituted in basic medium .