utaneous T-cell lymphomas are a heterogenous group of diseases, with mycosis fungoides (MF) and Sézary syndrome (SS) representing the most frequently encountered subtypes, accounting for 70-75% of all cases. 1-3 Histologically, proliferated atypical CD4+ T cells along with both CD4+ and CD8+ reactive lymphocytes are seen in MF. Clinical manifestations usually start as a non-specific eczematous eruption that evolves into indurated plaques and subsequently into tumours in a subset of patients. Involvement of lymph nodes and viscera may be noted. When peripheral HLA Type Determination in Patients Diagnosed with Mycosis Fungoides and Sézary Syndrome A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Mycosis fungoides (MF) and Sézary syndrome (SS) represent the most frequently encountered subtypes of primary cutaneous T-cell lymphoma. The human leukocyte antigen (HLA) system was shown to be involved in susceptibility to MF/SS in various studies involving populations of different genetic backgrounds. We aimed to determine the possible association of HLA system with MF/SS in Turkish cases. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 30 MF/SS cases underwent genotyping for HLA-A, HLA-B and HLA-DR loci. Samples from 30 healthy subjects were obtained as controls. R Re es su ul lt ts s: : Statistically significant associations were found between MF and HLA-A31, HLA-B51 and HLA-DR3 alleles. A significantly higher frequency of HLA-B35 and HLA-DR4 was noted in healthy controls as compared with the patients. C Co on nc cl lu us si io on n: : This study suggests that HLA genotypes are involved in susceptibility to MF. HLA-A31, HLA-B51 and HLA-DR3 alleles were considered as markers to disease susceptibility whereas HLA-B35 and HLA-DR4 alleles may be protective against neoplastic transformation. K Ke ey yw wo or rd ds s: : Disease susceptibility; HLA antigens; mycosis fungoides Ö ÖZ ZE ET T A Am ma aç ç: : Mikozis fungoides (MF) ve Sézary sendromu (SS) primer T-hucreli deri lenfomalarının en sık rastlanan formlarıdır. Farklı genetik zeminlerden toplumlarda yapılan çeşitli çalışmalarda hastalığın gelişiminde sınıf I ve II insan lökosit antijenlerinin (HLA) rolü olabileceği gösterilmiştir. Çalışmanın amacı, Türk hastalarda mikozis fungoides ve Sézary sendromu ile HLA sisteminin muhtemel ilişkisinin araştırılmasıdır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Mikozis fungoides ve Sézary sendromu tanısı olan 30 hastaya HLA-A, HLA-B ve HLA-DR lokuslarını değerlendirmek üzere genotipleme yapıldı. Sonuçlar 30 sağlıklı bireyin örnekleri ile karşılaştırıldı. B Bu ul lg gu ul la ar r: : HLA-A31, HLA-B51 ve HLA-DR3 alelleri ile MF arasında istatistiksel olarak anlamlı ilişki saptandı. Hastalarla kıyaslandığında, kontrol grubunda HLA-B35 ve HLA-DR4 sıklığında anlamlı yükseklik mevcuttu. S So on nu uç ç: : Çalışmamız HLA genotiplerinin MF'e yatkınlıkta rolü olabileceğini göstermektedir. HLA-A31, HLA-B51 ve HLA-DR3 alelleri hastalığa yatkınlığı göstermekte iken HLA-B35 ve HLA-DR4 alelleri neoplastik d...