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In the present work, novel configuration of rotating desiccant wheel using calcium chloride as the working desiccant is presented. The proposed system is called desiccant operated humidity pump (DOHP). Mathematical model, which can be applied for analysis of the proposed system, is developed. The proposed system can be powered by low grade heat sources such as solar energy. Absorption-regeneration cycle for the DOHP is described and analyzed. An expression for the efficiency of the simple cycle is introduced. Theoretical analysis shows that strong and weak solution concentration limits play a decisive role in the value of cycle efficiency. System efficiency with consideration of heat and work added to the system is well defined. Dimensionless parameters defining the system design parameters are introduced. The limits of regeneration temperature and mass of strong solution per kg of produced vapor are found highly dependent on the operating concentration of desiccant.