Caffeine is one of the world's most consumed drugs. According to the Washington Post (2015), two billion cups of coffee are consumed per day worldwide. Caffeine is classified as a central nervous system (CNS) stimulant and an organic molecule called methylxanthine. Caffeine has three notable mechanisms of action on the CNS that produce a psychostimulant effect. These effects are responsible for the effect that caffeine has on cognitive function. The effects of caffeine consumption on cognitive function have been demonstrated across several studies involving humans and animals. With the immense number of people consuming caffeine around the world, it is of vital importance to study the effects that this drug has on people's cognitive function. This literature review provides useful insights on this question through the analysis of caffeine's effects on cognitive function, along with information on caffeine's three modes of action. The findings of recent studies show mixed results regarding the effects of caffeine on mood, attention, processing speed, and memory. Current research suggests that if caffeine does have an effect on mood, the most significant changes may be anxiety. Studies did not support caffeine as having any significant effect on attention, but that it did play a role in enhancing processing speed. The majority of the studies reviewed suggest caffeine as having a significant positive effect on both short and long-term memory in adults and the elderly. Current findings warrant continued research on the association of caffeine and the resultant effects on cognitive function.

Introduction The greater palatine canal route has been well‐described in adults for the purposes of anesthetizing the branches of the maxillary division of trigeminal nerve for the relief of sphenopalatine neuralgia [11]. The canal also provides direct access to the contents of the PPF [12]. A complex array of vascular and neural structures characterizes this posterior maxillary region where the GPC is located. Its surgical anatomy can get further complicated by any anatomic variations and identification of vital structures becomes difficult, especially when bleeding during surgery obscures the region. Accurate knowledge of normal anatomy and common anatomical variations therefore remain crucial in minimizing intraoperative and postoperative complications associated with invasive microsurgical approaches to this region. The aim of this study was to explore the architecture of the GPC for any anatomic variations. Material & Method In total, 30 adult dried and intact skull specimens were selected. The selection criteria included an intact hard palate with erupted 3rd molars and an intact lateral nasal wall on both sides. The exclusion criteria included any major craniofacial deformities, excessive bone resorption, very old specimens. The bony walls of the GPC were observed by passing a black wire. Findings 4 out of 30 specimens showed marked variations in the bony medial wall of the greater palatine canal (GPC). Partial to complete malfusion between the posterior surface of the maxilla and the perpendicular plate of palatine bone was observed. This might be the result of embryological malformation. Conclusion The present study provided information regarding the existence of some degree of anatomical variation in the bony architecture of greater palatine canal. Significance This might help surgeons visualize over the possibility of the existence of any such variation while performing any surgical procedure in the posterior maxillary area. In order to establish the embryological basis of these findings, investigation on a larger number of specimens is highly suggested by the authors.