inner filter effect make a separation necessary. Salicylamide is not too soluble in aqueous acid so that some of it is eliminated in the dissolution step. The remainder is removed by an ether extraction.Sominex tablets were analyzed in triplicate by the procedure outlined in the Experimental section. Samples spiked with standard methapyrilene hydrochloride solu-tion were analyzed to determine the recovery. The mean of the results (Table VI) for methapyrilene was 0.9 mg higher than the stated amount of 25 mg on the label, a reasonable deviation.