Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used analgesic medications in human and veterinary medicine. In osteoarthritis they are used for their anti-inflammatory and analgesic actions. A number of NSAIDs are licensed for use in dogs in the UK, and are affordable and easy to administer. However, their use is associated with a range of side effects, which can become particularly relevant in cases that require long-term treatment. This article reviews the adverse effects of NSAIDs and the current monitoring procedures in animals and people on long-term NSAID therapy. Emerging and alternative procedures for monitoring these patients are also discussed.

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