The choice of treatment of carotid artery stenosis is firstly based on assessment of the degree of stenosis and embologeneity of the atherosclerotic plaque. But even in "good-risk" population it is still difficult to identify the patients who are particularly at high threat of stroke and would most benefit from carotid reconstruction. Along with common criteria numerous studies also focus on a prognostic role of a cerebrovascular reserve (CVR) and its state which allows to carry out more objective and pathogenetically substantiated selection of cases for surgical and medical treatment. The present study is a literature review of CVR assessment with different methods in relation to the clinical course of disease, severity of stenosis, the state of collateral circulation, its dynamics after operative procedures. Questions are discussed about the informative value of CVR indices in predicting ischemic strokes and postoperative hyperperfusion complications. It was concluded there is a great need for carrying out multicenter randomized studies to determine the prognostic role of CVR in the choice of treatment strategy, to clarify the indications and evaluate the effectiveness of surgical intervention in patients with stenotic lesions of the internal carotid arteries.

The expression of mRNA of proteins involved in the transformations of cytostatics (cytochrome P-450 1A1 and 1B1 isoforms) and genes encoding proteins participating in their regulation (Ah receptor, AHRR and ARNT) in intestinal tumors and intact portions of the intestine were studied. The expression of cytochrome P-450 1A1 increased in poorly differentiated tumors in comparison with its expression in intact portions of the intestine (tumor/intact tissue=1.65). The expression of cytochrome P-450 1B1 was higher in well-differentiated tumors (tumor/intact tissue=1.62). The possibility of practical use of high expression of cytochrome P-450 isoforms in tumors in comparison with intact intestinal tissue is discussed.

Immunochromatographic test systems to determine X‐, Y‐, S‐, M - virus and virus of potato leaf roll were developed and tested. It was shown that the detection limit of 10 ng/ml, regulated by state standard 33996-2016, was achieved by selecting the conjugate pad, as well as optimizing the parameters of the marker-antibody conjugate and the composition of buffer working solutions.