Religion is nowadays recognized as an important potential resource for coping (both helpful and harmful). This quasi-experimental study examined the effect of an adjunctive online and at home psychoeducational module aimed at sustaining positive religious coping and diminishing negative religious coping (E-health module on religious coping; E-RC module) among Christian outpatients with depression or anxiety disorder. A number of 131 participants were assigned to (a) an E-RC module group or (b) a control group, eventually on a 2:1 ratio. Both groups received blended care: a mix of care as usual (i.e., face-to-face sessions) and e-health: (a) E-RC module or (b) online cognitive behavioral interventions. Self-report questionnaires (measuring religious coping-Brief RCOPE-and well-being-Mental Health Continuum-Short Form; MHC-SF) were administered at pre-treatment (T0), after 3 months (T1), and after 6 months (T2) of therapy. We used linear mixed models with random intercepts as statistical analyses. A total of 69 participants completed all measures (ER-C module N = 33; control N = 36). No relevant differences between the groups in reported general well-being or religious coping patterns over time were found. In both groups, negative religious coping was significantly related to well-being. Because of the study sample (highly committed Christian people), the relative high level of drop-out and issues in the study design, results are not unambiguously interpretable. The results do not support the expected effect of the ER-C module. Future research is needed to replicate our study aim in a design that provides more detailed information about religious coping and its interaction with treatment outcomes.