Introduction:We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fi brosis regression after specifi c treatment for schistosomiasis. Methods: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specifi c treatment to estimate the probability of periportal fi brosis regression. Results: There was no evidence of associations between IL-10 polymorphisms and periportal fi brosis regression after treatment. Conclusions: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fi brosis in this Brazilian population.

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