Non-viral cationic liposome/DNA complexes (lipoplexes) have been used extensively in gene delivery approaches, although they have shown lower efficiency compared to viral carriers. In this study, a rational strategy was employed taking advantage of a combination of cationic liposomes prepared using the cationic cytofectin MSO9 and a folate ligand to create a more selective and effective gene delivery system to target cancer cells that overexpress the folate receptor (

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