Key Points
Both Notch1 and Notch2 receptors are involved in pre-HSC maturation. Developing HSCs become Notch independent by the end of their maturation in the AGM region.
Through transcriptional profiling of the mouse AGM region, McGarvey et al. identify potential niche regulators of HSC development. They show a new function of BMPER in regulating HSC maturation, likely via its modulation of BMP signalling.
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