Highlights
vYF-247 was cloned from YF-VAX and adapted for growth in serum-free Vero cells.
vYF-247 selected by safety/immunogenicity/efficacy criteria in small animal models.
vYF-247 was less neurovirulent than Stamaril and YF-VAX.
vYF-247 had similar attenuation profile, viscerotropism, neurotropism and immunogenicity to YF-VAX.
vYF-247 protects hamsters from lethal challenge with yellow fever Jimenez P10 virus.
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