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metabolic processes and transcription from RNA polymerase type II promoter. The main molecular functions enriched were the protein, enhancer, chromatin, and transcription factor binding. In particular, the transcription factors ZF5, E2F, and Kaiso showed the highest statistical significance.CONCLUSIONS: IVF modifies the DNA methylation signature in the adult liver, resulting in the hypomethylation of genes involved in metabolism and regulation of gene transcription. These findings may shed light into the mechanisms underlying the developmental origin of health and disease.SUPPORT: R01HD092267 to PFR and UC MEXUS-CONACYT to SLA.

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