Objective: A literature review of major publications was conducted to describe the epidemiology and trends over time of diabetes mellitus in Greece.Results: Although studies differ regarding methodology (self-reporting or data recording versus blood glucose measurements and OGTT), there is an increase in the prevalence of diabetes in the Greek population. In the Attica region, prevalence increased from 2,4% in 1974 to 9,5% (self-reporting studies) or 11,6% (blood glucose measurements and OGTT) in 2006. Regarding rural population, where prevalence was almost negligible (1,5%) during 1988-1993, there was a dramatic increase (approximately 11,7% during 2003-2005), to become equal to urban population. This change is similar to the trends worldwide. The cause of this increase is lifestyle change, with a consequent decrease in the physical activity, junk food, and obesity. Prevalence is higher in lower socioeconomic status. Intervention is important to decrease diabetes incidence by modifying modern lifestyle.