The drugs mostly present are available with less bioavailability  and the problem arises with less permeation or solubility  so extensive work is done to enhance these mechanisms. Not only that drugs should pass hepatic metabolism, Inorder to improve its bioavailability they are formulated as transferosomes which can improve the patient compliance by delivering the drug through the transdermal-route. Soya lecithin is used as a phospholipid whereas Tween 60, Tween 80, Span 60 and Span 80 are used as edge activators. These formulations usually showed more entrapment efficiency. The reason behind this is due to the presence of more phospholipids and as the surfactant concentration increases drug release will be rapid. As our main aim is to enhance the bioavailability this can be achieved by optimizing the concentrations of phospholipid and surfactant one can attain a controlled release of drug through this drug delivery system.