Both methods using bone marrow stromal cells contributed to enhancing bone healing, especially that using the bone marrow mononuclear fraction. The use of a barrier membrane seemed to have a synergistic effect.

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In spite of their osteoconductive potential, the biomaterials used as substitutes for an autologous graft do not show osteoinductive or osteogenic potential. This study evaluated the association of adult mesenchymal stem cells derived from adipose tissue with xenogenic bone graft in bone regeneration in rabbit calvaria. Materials and Methods: Mesenchymal stem cells were harvested from adipose tissue from 12 animals. These cells, combined with hydroxyapatite, were implanted in 12-mm bilateral bone defects created in the calvaria of six rabbits (test group [TG]), whereas only hydroxyapatite was implanted in the defects created in another group of six animals (control group [CG]). One grafted side of each animal was covered by a collagen membrane. After 8 weeks, the animals were sacrificed, and the region of the bone defects was removed and evaluated using histomorphometry and immunohistochemistry. Results: The TG showed higher amounts (P < .05) of vital mineralized tissue and nonvital mineralized tissue, 28.24% ± 6.17% and 27.79% ± 2.72%, respectively, compared with the CG, 13.06% ± 5.24% and 13.52% ± 3.00%, respectively. In TG, no difference was observed (P > .05) in the amount of mineralized tissue between the side that was covered by the membrane vs the side without membrane coverage. On the other hand, a statistically significant difference (P < .05) was observed in the CG with regard to the amount of mineralized tissue between the sides with and without membrane coverage. Conclusion: These observations suggest that the association of mesenchymal stem cells derived from adipose tissue with a xenogenic bone graft was capable of promoting better bone regeneration compared with the use of a xenograft alone. Use of a membrane did not produce an increase in the regenerative potential for the TG, in contrast to the CG.

RESUMOA hipófise e a região selar podem ser acometidas por uma série de tumores. Nesse PALAVRAS-CHAVENeoplasia do colo, hipófise, metástase neoplásica. ABSTRACT Metastatic colonic adenocarcinoma from sellar region: case report The pituitary gland and sellar region may be a site for a number of tumors. In this context a rare but feasible differential diagnosis is metastasis. The diagnosis of metastasis in the sellar KEY-WORDSColonic neoplasm, pituitary gland, neoplasm metastasis.

Trabalho número 292, apresentação oral no XVII Congresso da Academia Brasileira de Neurocirurgia, Goiânia, 14 a 17 de junho de 2017. RESUMO Introdução:A distonia pode ser definida como um distúrbio neurológico com a presença de movimentos involuntários com contrações espasmódicas. A estimulação cerebral profunda (DBS) é considerada altamente efetiva em pacientes criteriosamente selecionados e avaliados. A maior efetividade da ECP é demonstrada principalmente nos casos de refratariedade do tratamento clínico e farmacológico na distonia cervical. Objetivo: realizar uma revisão de literatura comprando os resultados da Estimulação Cerebral Profunda no Globo Pálido Interno (GPi), analisando os resultados obtidos no tratamento da distonia focal e segmentar. Métodos: Foram pesquisados no banco de dados do MEDLINE artigos descrevendo DBS para distonia por meio de palavraschave. Resultados: Foram identificados 308 artigos que envolvem estudos no tratamento de distonia com DBS no GPi. Após aplicar os filtros na base de dados "MEDLINE", 48 artigos foram excluídos, restando 260 artigos elegíveis. Posteriormente, realizou-se uma revisão minuciosa dos artigos publicados na plataforma em questão. Conclusões: Aponta-se que pacientes com distonia primária são mais beneficiados pelo DBS quando eletrodos são inseridos na porção ventromedial do GPi com taxas de efeitos adversos aceitáveis. Um melhor prognóstico desses pacientes depende de um acompanhamento interdisciplinar individualizado no período pré e pós-operatório. ABSTRACT Introduction: Dystonia can be defined as a neurological disorder characterized by involuntary movements with spasmodic contractions. Deep brain stimulation (DBS) is considered highly effective in critically selected and evaluated patients. The greater effectiveness of DBS is demonstrated mainly in cases of clinical and pharmacological treatment of refractory cervical dystonia.Objective: This paper aims to review the literature comparing the results of the DBS at Globus Pallidus internus (GPi), analyzing the results obtained in the treatment of focal and segmental dystonia. Methods: We searched at MEDLINE database for articles describing DBS for dystonia using keywords. Results: We identified 308 articles involving studies in the treatment of dystonia with the GPi DBS. After applying filters in "MEDLINE" database, 48 articles were excluded, remaining 260 eligible articles. Subsequently, a thorough review of the articles published on this platform was carried out. Conclusions: it is pointed out that patients with primary dystonia are more benefited by DBS when electrodes are inserted in the ventromedial portion of the GPi with acceptable adverse effects rates. A better prognosis of these patients depends on an individualized interdisciplinary follow-up in the pre and postoperative period.