Diabetes mellitus (DM) and hypertension are two common diseases that often coexist. The most common cause of death in the diabetic patient is heart disease. In the present investigation we combine Nebivolol and Nateglinide for better patient compliance. IR layer was formulated using various superdisintegrants like Crospovidone, Croscarmellose sodium, and sodium starch glycolate and SR layer was formulated using polymers and gums like HPMC E15, ethyl cellulose, Gaur gum, and Xanthan gum. The disintegration and dissolution study of both layers showed that inclusion of surfactant (sodium lauryl sulphate) to the tablet formulation (IR) and dissolution medium (SR) enhanced the release of drugs from both layers. Kinetic studies of optimized IR layer (NBL8) and SR layer (N9) showed good linearity with regression coefficient of 0.9714 (Higuchi model) and 0.9931 (zero order kinetics), respectively. The above results reveal that the optimized IR layer of Nebivolol (NBL8) and SR layer of Nateglinide (N9) might be suitable for the treatment of diabetes and hypertension by sequential release of the two drugs in a bilayer tablet. IR-immediate release, SR-sustain release, NBL8-Nebivolol 8, N9-Nateglinide 9.

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Objective: The present Study was to identify more effective hypoglycemic fractions from chloroform extract of Albizia procera stem bark. Material and methods: Isolated fractions of Albizia procera stem bark chloroform extract were given individually to different batches of rats both normal (80 mg/kg of b.wt animals) and STZ induced diabetic rats (160mg/kg b.wt animals) after an overnight fast. The blood glucose levels were measured at 0, 1, 2, 3, 5 and 6 hours after the treatment. Fractions were also treated to STZ induced diabetic rats by chronically (80mg/kg b.wt). Results: The fractions E of Albizia procera stem bark chloroform extract was shown maximum blood glucose lowering effect in both normal and STZ diabetic rats with acute and chronic treatment. The other fractions are also showing hypoglycemic and antihyperglycemic activity, but the effect is significantly less than that of fraction E. The antihyperglycemic activity of fractions of Albizia procera stem bark chloroform extract was compared with the treatment of glibenclamide. Conclusion: The present data confirm the anti diabetic activity of Albizia procera in Indian traditional medicine for Diabetes mellitus treatment. The anti hyperglycemic action attributed to the presence of valuable flavonoids, terpinoids in the fraction E.

: Heliotropium indicum is a whole herb used as traditional medicine mainly in