Background: Acne is a widespread and complex skin disease among developed nations, affecting nearly all young adults between the ages of 15 to 17 years. It is a chronic inflammatory skin disorder resulting in psychological stress. Historically, the relationship between diet and acne is controversial. As a result, significant studies have been done to evaluate this relationship. Assessment of these literatures will help to provide better outcomes for the patients.Objective:This study aims to: 1-Measuring effect of diet and nutritional substances in the management and prevention of acne vulgaris. 2-Providing a reference paper analyzing all the clinical studies in this field. 3-Analyzing the last progression has been reached. Methods: PubMed database was used for articles selection. We included all relevant articles to our review with the following topics (("Acne Vulgaris/diet therapy"[Mesh]) AND ("Acne Vulgaris/prevention and control"[Mesh])) AND ("Acne Vulgaris/therapy"[Mesh]). We excluded other articles which are not related to this field. The data will be extracted according to specific form in which it is going to be reviewed by group members to assess the dietary effect of nutritional substance on acne vulgaris. Conclusion:We concluded that there are studies that showed promising results among patients and proved that associations do exist. Nevertheless, further studies with bigger sample and better protocols are needed to establish a concrete evidence-based relationship.