The aims of this study were to (i) analyze the physical and physiological responses of four matches competition and (ii) to investigate the relationships among three different pitch dimensions of small-sided game (SSG) on the youth soccer players. Fifteen male U19 soccer players (age 17.3 ± 0.5 years, height 175.7 ± 5.6 cm, weight 68.5 ± 8.6 kg, playing experience 7.8 ± 1.4 years) were randomly assigned to three play areas: small (50 m2), medium (SSG-m, 150 m2) and large (SSG-l, 250 m2) area per player including goalkeeper. During the 4-week intervention, both groups performed three sets of 8 min with a passive rest period of 5 min between games. Differences in time-motion characteristics of players were measured with the Global Positioning System and assessed using a repeated measures ANOVA to compare the three game conditions and the magnitude-based inference to evaluate the pairwise comparison effects. The results showed that only the variables distance covered between 7.0–12.9 km·h−1 was not statistically significantly different among game conditions (p < 0.05; η = 0.21; small) and physiological response (i.e., hear rate of playing time spent 85–89% HRmax) also showed differences (p < 0.05; η = 0.25; small). The responses in SSG-m and SSG-l established them ass the format sizes ideal for replicating the physical responses during match competition. These findings could provide relevant information for coaches for use adequate pitch size (areas of 150 m2 and 250 m2) to reach the match-play scenarios found in match competition.