Sugars are a versatile tool for targeting malignant cells
and have
been extensively used for drug delivery and imaging techniques. Their
prototype, fluorodeoxyglucose ([18F]FDG), is currently
used for positron emission tomography. Boron neutron capture therapy
(BNCT) is a cancer treatment that relies on irradiation with thermal
neutrons of cancer cells previously loaded with [10B]-containing
compounds. The recent introduction of accelerators as a neutron source
for clinical use prompts the planning of delivery compounds enriched
with boron able to be traced in real time. This work describes the
first synthesis of a new class of sugar derivatives conjugated to
a trifluoroborate moiety as potential theranostic agents. Stability
and cytotoxicity studies are reported for all compounds, together
with [18F] radiolabeling optimization and in vivo preliminary positron emission tomography (PET) experiments on a
selected compound.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.