Seizures remain uncontrolled in 30% of patients with epilepsy,

We report a Seoul-Fluor-based bioprobe, SfBP, for selective monitoring of protein tyrosine phosphatases (PTPs). A rational design based on the structures at the active site of dual-specific PTPs can enable SfBP to selectively monitor the activity of these PTPs with a 93-fold change in brightness. Moreover, screening results of SfBP against 30 classical PTPs and 35 dual-specific PTPs show that it is selective toward vaccinia H1-related (VHR) phosphatase, a dual-specific PTP (DUSP-3).

Phosphatase. -The title compound SfBP (IV) is readily prepared by phosphorylation of known precursor (I) followed by deprotection of phosphodiester (III) with bromotrimethylsilane. -(JEONG, M. S.; KIM, E.; KANG, H. J.; CHOI, E. J.; CHO, A. R.; CHUNG*, S. J.; PARK, S. B.; Chem. Commun. (Cambridge) 48 (2012) 52, 6553-6555, http://dx.doi.org/10.1039/c2cc31377d ; Korea Res. Inst. Biosci. Biotechnol., Daejeon 305-806, S. Korea; Eng.) -R. Staver 43-191