While almost all the students used SM, only a minority used them for academic purposes. SM use was not associated with academic performance.

Sural nerve autografts were performed on intact rat sural nerves and on sural nerves excised proximal to the site of grafting. The effect of the presence or absence of regenerating axons upon reconstitution of the perineurium at the graft junctions and upon re-establishment of the blood-nerve barrier to horseradish peroxidase (HRP) were studied over the succeeding 3--24 weeks. Compartmentation of the nerve fascicle occurred at the graft junctions where the perineurium was damaged. Each compartment contained Schwann cells with or without axons and was surrounded by elongated fibroblast-like cells which resembled perineurial cells in the longer surviving animals. It was concluded that, (a) compartments form in a nerve at the site of perineurial damage even in the absence of axons; (b) although compartmentation may be a mechanism for perineurial regeneration and reconstitution of the blood-nerve barrier, blood vessels and the cell layers forming compartments at graft junctions remain permeable to HRP for at least 6 months; and (c) the intact perineurium around the distal stump of a denervated nerve is permeable to HRP but the endoneurial blood vessels are not.

Background:The efficacy of an extract from date seeds has been tested successfully on the glycemic control of type I diabetes mellitus in rats. A suggestion that date seed extract could stimulate certain cells to differentiate into insulin-secreting cells has been proposed. In order to investigate such a possibility, this study was conducted to measure C-peptide levels in the serum of type 1 diabetic rats treated with date seed extract. Methods:Two hundred rats were divided into 4 groups. Group I served as the control. Group II was given daily ingestions of 10 ml of date seed extract. Groups III and IV were made diabetic by streptozotocin injection and were given daily subcutaneous injections of 3 IU/day of insulin for 8 weeks. Group IV received, in addition, daily ingestions of 10 ml of seed extract. At the end of experiment, blood samples were collected from each rat, and blood glucose and serum Cpeptide levels were measured.Results: No significant differences in the means of blood glucose and serum C-peptide levels were observed between groups I (control group) and II (date seed extract-treated control group). Group IV (date seed extract-insulin-treated diabetic group) showed a statistically significant reduction in the mean blood glucose level compared to Group III (insulin-treated diabetic group). The mean serum C-peptide level was significantly higher in group IV compared to group III. Conclusion:Biochemical results suggested an increase in endogenous insulin secretion in the case of type 1 diabetic rats treated with date seed extract, which might be the cause of its hypoglycemic effect. BACKGROUND:Diabetes is a predominant public health concern affecting a large population in the whole world. The disease causes substantial morbidity, mortality, and long-term complications [1,2]. Insulin is the only drug currently available to treat type 1 diabetes mellitus (T1DM), and its disadvantages have been discussed in previous studies [3,4]. There is an increasing use of complementary and alternative medicine among general public [5]. In a previous study, we successfully tested the efficacy of an aqueous extract from date seeds on the glycemic control of T1DM in rats [6].In another study, we demonstrated the safety of date seed extract administration on liver and kidneys of rats, and showed that a date seed extract-insulin combination minimizes the diabetic toxic effects on the liver and kidneys of rats, compared to insulin administration as a single drug [7]. However, the potential mechanism by which date seed extract exerts its hypoglycemic effect remains uninvestigated. A suggestion that such an extract could stimulate certain cells to differentiate into insulin-secreting cells has been proposed [6].C-peptide (connecting peptide), a 31-amino-acid polypeptide, represents the midportion of the proinsulin molecule. During insulin secretion, it is enzymatically cleaved off and cosecreted in equimolar proportion with mature insulin molecules. Because synthetic insulin does not have such a peptide, the level...

Background and Objectives: Learning is an interplay between cognition and environmental factors. Any learning environment, that fulfills the intrinsic and extrinsic needs of the students will probably lead to better and more promising learning outcomes. This study aimed to investigate the student perceptions of Learning Environment (LE) in four health schools of a large university and compare between schools, years of study, and gender. Methods: Dundee Ready Education Environment Measure (DREEM) questionnaire and a socio-demographic questionnaire were completed by 1185 undergraduate students enrolled in the school of Medicine, Dentistry, Nursing and Applied Medical Sciences (AMS) of a large university during the academic year 2012-2013. Chi-square test was used to compare categorical variables. Independent student t-test or ANOVA (with Tukey post-hoc test) was used for continuous variables at a significance level of p ≤ 0.05. Results: The mean total DREEM score was 89.23±33.3. The total DREEM mean scores for Dentistry (120.54±23.45) and Medicine (110.72±19.33) were higher compared with AMS (63.48±21.36) and Nursing (57.48±22.80) (p=0.000) (Post hoc Tukey p=0.000). First year students gave significantly higher positive perceptions ratings than the rest of the years (p=0.000). Total scores were significantly higher for male (92.78±33.86) than female students (84.70±32.25) p=0.000. Conclusion: The LE significantly differed by year and gender. The students from non-integrated curricula (nursing and AMS) perceived the LE less positively than their integrated curriculum counterparts (medicine and dentistry). A qualitative study is needed to investigate the variation in the perception of LE among these groups. doi: https://doi.org/10.12669/pjms.35.3.712 How to cite this:Irfan F, Al-Faris E, Al-Maflehi N, Karim SI, Ponnamperuma G, Saad H, et al. The learning environment of four undergraduate health professional schools: Lessons learned. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.712 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BackgroundMedical students are faced with enormous academic demands that may influence their emotional wellbeing. The high rate of depression among medical students and its negative impact is an impetus to find explanation for the factors associated with it. Study skills that students possess might be such a factor. The current tools for the assessment of the study skills may have certain limitations, particularly for different cultural settings.ObjectivesThis study aimed to develop and validate a Study Skills Inventory (SSI), and to investigate the relationship between the students’ study skills and the extent (severity) of depressive symptoms, measured using the validated tool.MethodThe first version of the SSI was developed through expert consensus. The inventory was then administered to a randomly selected group of medical students. Confirmatory factor analysis was conducted for the internal validity. External validation was conducted by comparing the results of the SSI with the “Approaches and Study Skills Inventory for Students” (ASSIST). After validation, the correlation between the SSI total score with the Beck Depression Inventory II (BDI-II) total score was investigated using the Pearson correlation coefficient. The means of the total study skills scores for each severity category of depression were compared using ANOVA.ResultsA total of 23 items, representing five sub-scales, were included in the inventory. Based on 372 student responses (response rate of 93%), the five-factor solution explained a cumulative variance of 52% and Cronach alpha was 0.84. The SSI total score had a significant negative association with the BDI-II depression score (Pearson correlation of -.348** and P<0.0001).ConclusionThis study showed evidence for acceptable reliability and validity of the newly developed SSI. Poor study skills were found to correlate with higher depressive symptoms. This association needs confirmation in future research and could open a new door for better understanding of student depression.