Kaposi's disease is rare in children. We report a mucocutaneous form revealing a co-infection HIV-viral hepatitis B associated with a Lutz-Lewandowski verruciform epidermodysplasia on sickle cell AC. This is a 14 year old boy received in a context of general deterioration. He had angiomatous plaques on the face, the mucous surface of the upper eyelid of the left eye, the trunk, the back and the limbs. His face had pityriasiform, finely scaly papular lesions suggestive of Lutz-Lewandowski's verruciform epidermodysplasia. Complementary examinations showed hypochromic microcytic anemia, positive retroviral serology and Hbs antigen. He was sickle cell type AC. Both HIV serology and Hbs antigen testing were positive in the mother. He was put on triple antiretroviral therapy and the course was unfavorable with death after 3 weeks of hospitalization. Our observation describes a rare case of childhood Kaposi's disease, revealing HIV-viral Hepatitis B co-infection associated with Lutz-Lewandowski's verruciform epidermodysplasia on AC sickle cell.