Background: Evaluate the shear bond strength (SBS) of pressable ceramic bonded to four core materials. Methods: Sixty-four cylinders of IPS e-max Press were fabricated. Disc-shaped specimens (n=16) of (IPS e-max ZIRCAD), Composite resin (Te-Econom Plus), and resin-modified glass ionomer (RMGIC) (GC FUJI II LC Capsule) were fabricated according to manufacturer recommendations. Sixteen molars were embedded in acrylic resin then their occlusal surfaces were grounded to flat dentin. Each core group was divided into two subgroups (n=8) according to cement type, either adhesive resin cement (Multilink N, Ivoclar Vivadent) or self-adhesive resin cement (Breeze, Pentron Clinical Technologies). Ceramic cylinders were bonded to core materials. All bonded specimens were stored in a water bath for five months at 37°C, then thermocycling for 5000 cycles. SBS test was performed using a universal testing machine at 0.5 mm/min. A stereomicroscope was used to determine the failure mode, followed by SEM examination. Data were analyzed using Two-way ANOVA, serial one-way ANOVAs at each level of study, and Tukey's HSD test at (p=0.05). Results: There was a statistically significant difference between different test groups, with the highest mean SBS for composite resin groups followed by RMGI groups and the lowest mean SBS for dentin groups followed by zirconia groups with no significant difference regarding cement type. Conclusion: Different core materials affected the SBS of pressable ceramic, while the cement type had no effect.