Atrophic acne scarring can affect about 75% of patients and is associated with social and psychological distress. Acne scars are classified into atrophic and hypertrophic types. 1 The atrophic type includes ice picks, boxcar, and rolling scars. Acne scarring is resulting from a consequence of abnormal wound healing which follows damage in the sebaceous follicles that may occur during the active stage of acne. 2,3 Recently, there has been a renewed interest in subcision.It can be used alone or as a part of the therapeutic plan. Subcision means using a special needle introduced under scarred tissue to cut the fibrous tissue causing a release of the scarring. [4][5][6] Multiple treatment modalities have been used for the treatment of acne scars as fractional laser and peeling but subcision has the advantage of safety use particularly in the dark skin type compared to lasers or peeling. Subcision is a mild invasive technique utilized to treat atrophic acne scars, post-surgical scars, and striae distensae. 7 It was reported that using cannula subcision in the treatment of acne scarring

Background: Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. The intraregional use of insulin ensures its absorption, greater stability, longer activity period and absence of contact with necrotic or enzymatic materials capable of preventing or changes its activity in topical use. Objective: in this article, we aimed to study the role of insulin in dermatology and skin diseases. Methods: We searched online databases (PubMed, Embase, and the Cochrane Library), to include studies that discuss the role of insulin in skin diseases, all types of studies are included. Conclusion: Insulin therapy has been shown to be effective and without adverse effects. Different intervals between applications did not change the obtained results. The availability of insulin and the safety of its use indicate the authors' method as an advantageous therapeutic option in the recovery of tissues. The availability, low cost and wide knowledge available on this substance justify its indication as a therapeutic method for, are difficult to heal wounds.