Diabetes mellitus is one of the highest global health emergencies of the 21st century, and the Kingdom of Saudi Arabia (KSA) has one of the highest prevalence rates of type 2 diabetes prevalence all over the world. Diabetes mellitus is a chronic disease that requires long-term medical attention to limit the development of its complications and manage them when they occur. Therefore, patients with diabetes have a greater risk of psychological problems, such as depression, stress, and anxiety, than people without diabetes. The study aims to estimate the prevalence and levels of depression, anxiety, and stress among type 2 diabetic patients and to identify the possible predictors of depression, anxiety, and stress among type 2 diabetic patients in Al-Madinah, Saudi Arabia. A cross-sectional design was conducted at primary healthcare centers affiliated with the Ministry of Health (MOH) in Al-Madinah City. This study observed that 3.3% of diabetes patients have depression from mild to moderate levels (2.5%, and 0.8%, respectively). The 34.4 diabetes patients had anxiety from mild to severe levels (17.6%, 11.6%, and 0.3%, respectively). 29.6% of diabetes patients had mild to extremely severe stress levels (10.6%, 19.8%, 3.8%, and 0.2%, respectively). These findings also suggest that the healthcare system must pay attention to the psychological aspects of diabetes and routinely request the screening and continual monitoring of DASS in diabetic patients.

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