No abstract

Coumarin derivatives have progressively enticed medicinal chemists because of their potential role in preventing and treating ailments. They epitomize a key motif nucleus in heterocyclic chemistry and a privileged structure in medicinal chemistry because of its extensive-range pharmacological activity. Regardless of the advancement in medicine over the past century, cancer is still remain the prominent source of death in the world and it makes indispensible needs to synthesize the compounds with coumarin as the core nucleus. Synthesis of various coumarin derivatives and evaluation of their pharmacological effects can perceive a solution to certain enigmatic demands in health sector. This review article is fixated on different synthetic routes of coumarin nucleus containing compounds. The review article also highlights different biological activities such as anticancer, antibacterial, anti- inflammatory, antihyperlipidemic and enzyme inhibition activities.

The benzoxazole is a heterocyclic aromatic organic compound. It is a vital pharmacophore and honoured structure in medicinal chemistry. It plays a very imperative role with quite useful therapeutic activities such as antiulcers, antihypertensives, analgesic, antiinflammatory, anti-virals, antifungals, anticancer, antidepressant activity, antilishmanial activity, anticonvulsant activity, antitubercular activity, antitumor activity, The review of the literature reveals that the benzoxazole derivatives are marvellously effective compounds and a large number of reviews available for biochemical and pharmacological studies established that their molecules are useful against a wide variety of microorganisms. Because of their prominence, the techniques for their synthesis have become an attention of synthetic organic chemists. Therefore, in the contemporary review we tried to assemble the chemistry of different derivative of substituted benzoxazole as well as various pharmacological activities and some of the important methodologies used for the synthesis.