Introduction: We aimed to analyze trends in Schistosomiasis positivity, mortality, and hospitalization rates in Northeast Brazil. Methods: We conducted an ecological study using data from the Brazilian Schistosomiasis Control Program, and Hospital and Mortality Information Systems. A joinpoint regression model was used for temporal analysis. Results: The positivity(−4.7%;p<0.001) and hospitalization(−17.7%;p<0.001) rates declined globally, while the mortality remained stationary (−0.8%;p>0.05). However, the hospitalization in Alagoas(27.1%;p<0.001) and Pernambuco (35.1%;p<0.001), and the mortality in Bahia(2.9%;p<0.001) and Sergipe(4.1%;p<0.001), increased. Conclusions: Schistosomiasis mansoni represents an important public health problem in Pernambuco,

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