The use of illicit substances can lead to several changes in physical and mental health, which can directly reflect on functional capacity and quality of life. However, there is a lack in the literature on the comparison of these variables between drug addicts and healthy individuals. To compare lung function, functional exercise capacity and quality of life of chemical dependents in rehabilitation process (CDRP) and apparently healthy individuals (AHI). Cross-sectional study that evaluated two groups (CDRP and AHI) matched by gender, age and BMI. Both groups were assessed for lung function (spirometry), quality of life (Short Form 36 questionnaire - SF-36), functional exercise capacity (6-minute walk test - 6MWT, 4-meter gait speed, Timed-up-and-go, Sit-to-Stand and Short Physical Performance Battery). Fifteen men in the CDRP group (31[26-39] years; BMI 23±3 kg/m2) and fifteen men in the AHI group (30[22-34] years; BMI 24±3 kg/m2) were analyzed. The CDRP group had a shorter distance covered in the 6MWT in meters (P=0.0002) and percentage of predicted (P=0.005). There was no difference in the performance of the other functional tests (P≥0.20) and in the pulmonary function (P≥0.46). The CDRP group had worse results in the functional capacity, pain, social aspects and mental health domains of SF-36 (P≤0.04), while in the domains general status, vitality, emotional and physical aspects there was no difference (P≥0.08). CDRP present similar lung function to AHI. However, the first have impaired functional exercise capacity, as well as some aspects of quality of life. Keywords: Drug Users. Motor Activity. Spirometry. Walk Test. Quality of Life. ResumoO uso de substâncias ilícitas pode levar a diversas alterações da saúde física e mental, o que pode refletir diretamente na capacidade funcional e na qualidade de vida. Porém, há uma escassez na literatura sobre a comparação dessas variáveis entre dependentes químicos e indivíduos saudáveis. Comparar função pulmonar, capacidade funcional de exercício e qualidade de vida de dependentes químicos em processo de reabilitação (DQPR) e indivíduos aparentemente saudáveis (AS). Estudo transversal que avaliou dois grupos (DQPR e AS) pareados por gênero, idade e IMC. Ambos os grupos foram avaliados quanto à função pulmonar (espirometria), qualidade de vida (questionário Short Form 36 – SF-36), capacidade funcional de exercício (Teste de Caminhada de 6 minutos - TC6, 4-metre gait speed, Timed-up-and-go, Sit-to-Stand e Short Physical Performace Battery). Foram analisados 15 homens no grupo DQPR (31[26-39] anos; IMC 23±3 kg/m2) e 15 homens no grupo AS (30[22-34] anos; IMC 24±3 kg/m2). O grupo DQPR apresentou uma menor distância percorrida no TC6 em metros (P=0,0002) e porcentagem do predito (P=0,005). Não houve diferença no desempenho dos demais testes funcionais (P≥0,20) e na função pulmonar (P≥0,46). O grupo DQPR apresentou piores resultados nos domínios capacidade funcional, dor, aspectos sociais e saúde mental do SF-36 (P≤0,04), enquanto que nos domínios estado geral, vitalidade, aspectos emocionais e físicos não houve diferença (P≥0,08). Homens dependentes químicos em processo de reabilitação apresentam função pulmonar semelhante a indivíduos aparentemente saudáveis. Entretanto, apresentam capacidade funcional de exercício prejudicada, assim como alguns aspectos da qualidade de vida. Palavras-chave: Usuários de Drogas. Atividade Motora. Espirometria. Teste de Caminhada. Qualidade de Vida.
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