Background: Chronic morbidity and also deaths are caused by COPD. Once affected by COPD, patients suffer many years together. Some can die before expected life expectancy. It has been estimated that due to constant exposure to risk factor and increased life expectancy, all over the world the prevalence is likely to increase.  The objective of the study was to study the clinical profile of patients with chronic obstructive pulmonary disease.Methods: A hospital based cross sectional study was conducted at department of community medicine, Late Baliram Kashyap Memorial Government Medical College, Jagdalpur, Chhattisgarh, India among patients with chronic obstructive pulmonary disease for a period of six months from September 2015 to February 2016. Informed consent was obtained from each patient. Detail clinical history, physical examination to look for nutritional status, spirometry with reversibility was carried out for each and every patient.Results: Age range in our study was 26-75 years. Mean age in COPD patients was 57.13±11.149 years and that of control group was 54.60±13.074 years with male to female ratio 9.71:1 in COPD case and 11.5:1 in control group. Most common symptom in COPD patient was SOB followed by cough, expectoration, and edema and chest pain. mMRC grading in COPD are higher than control group in our study. Smoking in pack year was significantly higher in COPD cases as 69.70± 36.164 and in control group it was 13.84±7.867.Conclusions: COPD was found to be more common in males. Cough was the most common presenting symptom. Smoking was significantly associated with occurrence of COPD.

Background: Hormones also take part in respiratory control via peripheral chemo receptors or by their local effects on the lungs and the airways. In chronic obstructive pulmonary disease patients, respiratory muscles are required to work efficiently than normal individuals to establish a sufficient respiration. Changes in serum hormone levels of COPD patients adversely affect functioning of respiratory muscles. Objective of the study was to assess endocrinal profile in COPD patient with comparable control groups.Methods: A Hospital based Case control study conducted at Department of Pulmonary Medicine, Late B.R.K.M Government Medical College, Jagdalpur, Chhattisgarh, India during July 2016 to January 2017. Study included 75 diagnosed cases of COPD in which moderate, severe, very severe COPD was 25 in each of this group (per GOLD ‘s guideline) and compared to age matched 25 healthy control.Results: In this study serum growth hormone and serum testosterone showed significant difference between COPD cases and control group and fair significant difference in serum FSH between COPD cases and control groups. There was no significant correlation between serum growth hormone, serum testosterone and serum FSH with COPD grading. There was no statistically difference observed in serum LH (p=0.425) level between COPD cases and control groups. Present study showed there was statistically difference in FT3, FT4 and TSH level between COPD cases and control groups. There was significant negative correlation between FT4 levels between COPD grading. But no correlation seen between COPD grading and control with respect to serum FT3 and TSH level.Conclusions: Endocrinal assessment in present study showed significant decrease in serum growth hormone and serum testosterone in COPD patients, which are anabolic hormones. Early detection and correction of such an anabolic hormonal abnormality may prevent skeletal and diaphragmatic muscle weakness, and improve respiratory drive of COPD patients.

Background: The potential ill effects of malnutrition are numerous, such as decreased maximal respiratory muscle force, decreased hypoxic Ventilatory response and decreased resistance to infection. The objective was to assess nutritional profile in chronic obstructive pulmonary disease (COPD) patient.Methods: The study was conducted at a tertiary care referral hospital. Period of study was one year. Present study was case control study. Institutional Ethics committee permission was taken. A total of 75 cases of chronic obstructive pulmonary disease and comparable controls were included in the study.Results: Present study shows that there was significant difference in mid arm circumference and mid-thigh circumference between COPD cases and control groups as well as between serum pre-albumin and serum transferrin level, serum uric acid (p=0.018) and serum calcium level (p=0.002). There was no statistically difference with respect to serum total protein (p=0.308), serum albumin (p=0.533) and serum phosphorus level (p=0.064) between COPD patient and control groups. There was statistically significant difference in total lymphocyte count between COPD cases and control groups as well as between serum LDL and serum HDL, serum LDL and serum HDL with COPD grading. As COPD grading increased there was significant decrease in serum LDL and serum HDL level. There was no significant difference with respect serum TG (p=0.738), VLDL and total cholesterol level (p=0.063) between COPD cases and control groups.Conclusions: Simple measurement of BMI, mid arm circumference and mid-thigh circumference can assess mal-nutrition in COPD patients and biochemical parameter like serum pre-albumin and serum transferrin may helpful in early detection of malnutrition.