Purpose : Parchment is a coffee by-products with high amounts of polyphenols that could be effective in the prevention of obesity-related metabolic disorders. However, their effectiveness depends on their stability and bioavailability which could be overcome by encapsulation. The aim of this study was to investigate anti-obesity effects of aqueous coffee parchment extracts.Methods : Aqueous coffee parchment extracts were administrated orally (100 mg/kg weight/day) as free or in a microencapsulated form with whey protein/maltodextrin, in fructose-induced obesity rat model (20% fructose in water). Different metabolic parameters were determined.Results : Parchment extract contained total phenolics at 79.50 mg GAE/ g, with chlorogenic acid and caffeine as main compounds. The microencapsulation e ciency was 89.36% and SEM images revealed spherical microcapsules which exhibited polyphenol release under simulated digestion. Fructose obese rats displayed increased adiposity and metabolic alterations as hyperinsulinemia, hyperglycemia, hyperlipidemia and oxidative stress with high liver and adipose tissue lipids. The treatment with parchment extracts prevented adipose fat accumulation and alleviated the hyperglycemia, hyperinsulinemia, hyperlipidemia, liver steatosis and oxidative stress in obese rats. The effects were more pronounced with encapsulation.Conclusion : Coffee parchment extracts protected against fructose-induced obesity metabolic alterations ; a better amelioration was observed with microcapsules which will increase the value of this coffee by-product. Statement Of NoveltyCoffee industry generates huge amounts of coffee wastes which are still rich in bioactive compounds with antioxidant activity. The by-product coffee parchment was less studied and less utilized. To our knowledge, no work has been done to investigate the possibility of encapsulating its bioactive compounds for better protection, delivery and use. For the rst time, we investigated the microencapsulation of coffee parchment extracts and we tested the metabolic effects of these microparticles in fructose induced obesity model. Our results suggested that coffee parchment extract treatment reduced adiposity, improved insulin resistance, lipid pro le and oxidant/antioxidant status. With encapsulation, bioactive molecules are less degraded, resulting in higher bene cial properties, providing valuable insight into their potential application in obesity treatment.

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