The structures of six new mycotoxins, penitrems A-F, isolated from cultures of Penicillium crustosum are deduced from their 13C and lH n.m.r. spectra and from biosynthetic results.
The observation of an NIH shift on incorporation of [2H3]acetate into aflatoxin B, in cultures of Aspergillus flaws provides evidence for the timing of deoxygenation and hydroxylation steps which are an essential part of the biosynthetic pathway.
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