Media. -The best biological results are obtained with title compound (IV) as a 50/50 mixture of diastereomers. (IV) is identified as the best inducer of sulfated glycosaminoglycans synthesis in vitro and is also proved to be active in a clinical trial. (IV) is the first example of a "Green" chemical used in cosmetic owing to its environmentally friendly synthesis and its biodegradation. -(CAVEZZA, A.; BOULLE, C.; GUEGUINIAT, A.; PICHAUD, P.; TROUILLE, S.; RICARD, L.; DALKO-CSIBA*, M.; Bioorg. Med. Chem. Lett. 19 (2009) 3, 845-849; Pers. Care Chem., L'OREAL Rech., F-93601 Aulnay-sous-Bois, Fr.; Eng.) -K. Schneider 26-196
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