Background: Research activities provide educators with valuable knowledge and skills. Publishing research articles, and presenting the findings at conferences are important among medical educators in their early academic career. However, the level of their research activity practice and affecting factors have not been investigated at Addis Ababa University. Objectives: Assessing the level of research practices and affecting factors among medical educators in an early academic career at Addis Ababa University, College of Health Sciences, School of Medicine Methods: One hundred ninety-five medical educators from all departments in the Scholl of Medicine have participated in this study. Proportional allocation and random sampling techniques were used to select each participant. Socio-demographic and other data were collected using self-administered pretested questionnaires. Data were entered and processed using SPSS version 21.0. Independent t-tests and one-way ANOVA were used. Results: The average number of articles published and presented at conferences per year in the last five years was low (.47±.35 and .45±.29, respectively). These publications were significantly higher among participants with a monthly salary of >10,470 than a monthly salary of ≤ 10, 470 (.45±.37 vs. .39±.28, p=0.03) Ethiopian birrs. Participants with moderate attitudes had published more articles than participants with less attitude towards CPD activities (.65±.43 vs. .20±.00, p=0.10). Medical educators with a higher academic experience of greater than fifteen years published more research articles than educators with an academic experience of fewer than five years (.80±.45 vs .39±.31, p=0.000). Participants from basic science departments presented more articles at conferences than participants from clinical science departments (.56±.29 vs. .39±.28, p=0.000). Conclusion: Research activities were low and affected by monthly salary, and field of the study. Effective research activity programs are crucial to improve research productivity among medical educators in their early academic career.